Gastrointestinal tract:
Often 1-10%: abdominal pain, sensations of bloating, diarrhea, nausea, constipation, flatulence, increased activity of "liver" enzymes, peptic ulcer with possible complications (bleeding, perforation), gastrointestinal bleeding;
Uncommon 0.1 - 1%: vomiting, jaundice, melena, the appearance of blood in the feces, the defeat of the esophagus, aphthous stomatitis, dry mouth and mucous membranes, hepatitis (possibly fulminant flow),
Rarely 0.01 - 0.1%: liver necrosis, cirrhosis, hepatorenal syndrome, appetite change, pancreatitis, cholecystopancreatitis, colitis.
Nervous system:
Often 1-10%: headache, dizziness;
Uncommon 0.1 - 1%: sleep disturbance, drowsiness, depression, irritability, aseptic meningitis (more often in patients with systemic lupus erythematosus and other systemic diseases of connective tissue);
Rarely 0.01 -0.1%: convulsions, weakness, disorientation,
Very rarely - less than 0.001%: including individual cases - nightmarish dreams,
feeling of fear.
Sense organs:
Often 1-10%: noise in ears;
Not infrequently 0.1-1%: blurred vision, diplopia, a taste disorder,
Rarely 0.01 -0.1%: reversible or irreversible hearing loss, scotoma. Skin:
Often 1-10%- skin itching, skin rash;
Uncommon 0.1 - 1%: areata, urticaria, eczema, chronic dermatitis, erythema multiforme, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome),
Rarely 0.01 - 0.1%: increased photosensitivity, small-point hemorrhage.
Genitourinary system:
Often 1-10%: fluid retention;
Uncommon 0.1 - 1%: nephrotic syndrome, proteinkriya, oliguria, hematuria, interstitial nephritis, papillary necrosis, acute renal insufficiency, azotemia.
Hematopoiesis and the immune system:
Often 1 to 10%: Anemia (including haemolytic and aplastic anemia), leukopenia, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura, worsening of infectious processes (development of necrotising fasciitis).
Respiratory system:
Not infrequently 0.1-1%: cough, bronchospasm, laryngeal edema, pneumonitis. The cardiovascular system:
Uncommon 0.1 - 1%: increased blood pressure; congestive heart failure, extrasystole, chest pain.
Allergic reactions:
Rarely 0.01 - 0.1%: anaphylactoid reactions, anaphylactic shock (usually develops rapidly), swelling of the lips and tongue, allergic vasculitis.