Diclofenac - instructions for use, dose, side effects, contraindications

Composition:100 g of gel contain Active ingredient: Diclofenac sodium in terms of 100% substance - 1.0 g. Excipients: Carbomer 940 (carbopol 980) - 1.7 g, methyl parahydroxybenzoate (nipagin) - 0.2 g, macrogol 400 - 35 , 0 g, polyester PE 240 - 5.0 g, ethyl alcohol 95% (ethanol) - 26.8 g, purified water - 30.3 g.

Description:A non-steroidal anti-inflammatory drug, a derivative of phenylacetic acid, has an anti-inflammatory and analgesic effect. Indiscriminately inhibiting cyclooxygenase 1 and cyclooxygenase 2, disrupts the metabolism of ara-I of chidonic acid, reduces the amount of prostaglandins, including in the inflammatory focus. When applied, it causes weakening or disappearance of pain in the place of application of the gel, pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints. Promotes an increase in the volume of movements in the affected joints.

Pharmacotherapeutic group:Non-steroidal anti-inflammatory drug (NSAID).

ATX: & nbsp

S.01.B.C.03 Diclofenac

M.01.A.B.05 Diclofenac

Pharmacodynamics:With the recommended method of applying the drug systemic absorption is not more than 6% of diclofenac. The connection with plasma proteins is 99.7%. It is excreted by the kidneys. When applied to the area of the affected joint, the concentration in the synovial fluid is higher than in the plasma.

Indications:Inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, psoriatic, juvenile chronic arthritis, ankylosing spondylitis, soft tissue rheumatism, gouty arthritis); traumatically caused inflammation of the tendons, ligaments, muscles and joints (as a result of stretching, with the load and bruises). Pain syndrome (lumbago, sciatica, neuralgia, myalgia, tendovaginitis, bursitis, rheumatic lesions of soft tissues); degenerative diseases of the musculoskeletal system (deforming osteoarthritis, osteochondrosis).

Contraindications:The use of the drug is contraindicated for hypersensitivity to diclofenac, aspirin or other non-steroidal anti-inflammatory drug; in case of hemopoiesis; with peptic ulcer of stomach and / or duodenum in the phase of exacerbation; during pregnancy,lactation; in childhood (up to 6 years); in violation of the integrity of the skin.

Carefully:Hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract, severe liver and kidney dysfunction, chronic heart failure, bronchial asthma, clotting disorders (including hemophilia, lengthening bleeding time, tendency to bleeding), elderly age, pregnancy I and II trimester.

Pregnancy and lactation:The drug should not be used in the III trimester of pregnancy. Experience in using the drug during lactation is not available. Use in I and II trimesters is possible only after consulting a doctor if the expected benefit to the mother exceeds the potential risk to the fetus.

Dosing and Administration:

Outwardly. Adults and children over 12 years of age, the drug is applied to the skin 2-3 times a day and lightly rubbed. The required amount of the drug depends on the size of the painful area. Single dose - up to 2 g (about 4 cm with a fully open neck of the tube). Children from 6 to 12 years of age should not be used more than 2 times a day, a single dose of the drug up to 1 g (about 2 cm with a fully open neck of the tube).After applying the gel, you should wash your hands.

The duration of treatment depends on the indications and the effect observed. After 2 weeks of use, consult a physician.

Side effects:The resulting side effects depend on individual sensitivity, the magnitude of the dose used and the duration of treatment. Possible allergic reactions from the skin (itching, skin rash, burning, hyperemia). With long-term use and / or application on extensive surfaces - systemic side effects due to resorptive action (generalized skin rash, bronchospasm, angioedema, photosensitivity). If any side effects occur, stop using the gel and consult a doctor.

Overdose:

Due to low systemic absorption when applying gel, an overdose is unlikely.

With accidental ingestion, it is possible to develop systemic adverse reactions. Treatment: gastric lavage, induction of vomiting, Activated carbon, forced diuresis, symptomatic therapy. Dialysis is not effective due to the high degree of binding to diclofenac proteins (about 99%).

Interaction:You should consult your doctor before applying Diclofenac if you are using other non-steroidal anti-inflammatory drugs.

Special instructions:Apply only to undamaged skin. After applying, do not apply an occlusive bandage. With prolonged use and / or application on extensive surfaces, it is possible to develop systemic side effects due to resorptive action. Avoid contact with eyes, mucous membranes or open wounds. Apply only externally.

Form release / dosage:

Gel for external use 1%.

Packaging:

30 g or 50 g in an aluminum tube. Each tube together with instructions for use. The change is placed in a pack of cardboard.

Storage conditions:In a dry, dark place at a temperature of 15. to 25 ° C. Keep out of the reach of children.

Shelf life:2 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:PL-000306

Date of registration:17.02.2011

Date of cancellation:2016-02-17

The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia

Manufacturer: & nbsp

TATHIMFARMPREPARATY, JSC Russia

Information update date: & nbsp14.02.2016

Illustrated instructions

Instructions

Diclofenac (Diclofenac)