The resulting side effects depend on individual sensitivity, the magnitude of the dose used and the duration of treatment. The concept of "sometimes" use in the event that side effects are observed in 1-10% of patients, "rarely" - in 0.001-1% of patients.
Gastrointestinal tract:
Sometimes - abdominal pain, a feeling of bloating, diarrhea, nausea, constipation, flatulence, increased levels of "liver" enzymes, peptic ulcer with possible complications (bleeding, perforation), gastrointestinal bleeding;
Rarely - vomiting, jaundice, melena, blood in stool, esophageal lesion, aphthous stomatitis, dry mouth, mucosal, hepatitis (fulminant possible), hepatic necrosis, cirrhosis, hepatorenal syndrome, appetite change, pancreatitis, holetsistopankreatit, colitis.
Nervous system:
Sometimes - headache, dizziness;
Rarely - sleep disturbance, drowsiness, depression, irritability, aseptic meningitis (usually in patients with systemic lupus erythematosus and other connective tissue diseases), cramps, weakness, disorientation, nightmares, feeling of fear.
Sense organs:
Sometimes - noise in the ears;
Rarely - blurred vision, diplopia, disturbance of taste, reversible or irreversible hearing loss, scotoma.
Skin:
Sometimes - itchy skin, skin rash;
Rarely - areata, urticaria, eczema, chronic dermatitis, erythema multiforme, includingStevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), increased photosensitivity, small-point hemorrhages.
Genitourinary system:
Sometimes - fluid retention;
Rarely - nephrotic syndrome, proteinuria, oliguria, hematuria, interstitial nephritis, papillary necrosis, acute renal failure, azotemia.
Hematopoiesis and the immune system:
Sometimes - anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura, worsening of the course of infectious processes (development of necrotizing fasciitis).
Respiratory system:
Rarely - cough, bronchospasm, laryngeal edema, pneumonitis.
The cardiovascular system:
Rarely - increased blood pressure; congestive heart failure, extrasystole, chest pain.
Allergic reactions:
Rarely - anaphylactoid reactions, anaphylactic shock (usually develops rapidly), swelling of the lips and tongue, allergic vasculitis.
Local reactions with rectal administration:
Rarely - irritation of the mucous membrane of the rectum, mucous discharge with an admixture of blood, pain during defecation, rectal bleeding.