On the part of the digestive system. More often 1% - abdominal pain, sensation of bloating, diarrhea, nausea, constipation, flatulence, increased level of "liver" transaminases, peptic ulcer, including with possible complications (perforation, bleeding), gastrointestinal bleeding without ulcers. Less often 1% - vomiting, jaundice, melena, the appearance of blood in the stool, the defeat of the esophagus, aphthous stomatitis, dryness of the mucous membranes (including the oral cavity), hepatitis (possibly lightning), liver necrosis, cirrhosis, hepatorenal syndrome, appetite change, pancreatitis, cholecystopancreatitis, colitis, u
From the nervous system. More often 1% - a headache, dizziness. Less 1% - insomnia, drowsiness, depression, irritability; aseptic meningitis (usually in patients with systemic lupus erythematosus and other connective tissue diseases), cramps, weakness, disorientation, nightmares, feeling of fear., spasm, weakness.
From the sense organs. More often 1% - noise in ears. Less than 1% - blurred vision, taste disturbance, reversible or irreversible hearing loss, scotoma.
From the skin. More often 1% - a skin rash, itching of the skin. Less than 1% - areata, urticaria, eczema, chronic dermatitis, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), increased photosensitivity melkotochechnye hemorrhage.
From the genitourinary system. More often 1% - fluid retention. Less than 1% - nephrotic syndrome, proteinuria, oliguria, hematuria, interstitial nephritis, papillary necrosis, acute renal insufficiency, azotemia.
From the organs of hematopoiesis and the immune system. Less 1% - anemia (including hemolytic and aplastic), leukopenia,thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura, worsening of the course of infectious processes (including the development of necrotizing fasciitis).
From the respiratory system. Less than 1% - cough, bronchospasm, laryngeal edema, pneumonitis.
From the cardiovascular system. Less than 1% - increased blood pressure, congestive heart failure, extrasystole, chest pain.
Allergic reactions. Less often 1% - anaphylactoid reactions, anaphylactic shock (usually develops rapidly) swelling of the lips and tongue, allergic vasculitis.