Diclofenac - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Has anti-inflammatory, analgesic effect. By indiscriminately inhibiting COX-1 (cyclooxygenase) and COX-2, it breaks the metabolism of arachidonic acid, reduces the amount of Pg (prostaglandin content), including in the inflammatory focus. Eliminates hyperthermia, pain, reduces edema, erythema in the place of application. When the inflammatory lesions of the joints contribute to reducing inflammatory swelling, swelling and morning stiffness, increasing the volume of movements, alleviating pain during movement. With this method of application, it practically has no systemic effect.

Pharmacokinetics:At application system absorption is no more than 6%.The connection with proteins is 99.7%. It is excreted by the kidneys. When applied to the area of the affected joint, the concentration in the synovial fluid is higher than in the plasma.

Indications:Rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, spondylarthrosis; rheumatic damage of periarticular structures, posttraumatic pain syndromes accompanied by inflammation, postoperative pain, gout.

Contraindications:Hypersensitivity to diclofenac (including other non-steroidal anti-inflammatory drugs) and other components of the drug, erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation), complete or incomplete combination of bronchial asthma, recurrent nasal polyposis or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including history), hematopoiesis, pregnancy (III trimester), younger children (up to 6 years), lactation period, violation of the integrity of the skin.

Carefully:

Hepatic porphyria (exacerbation), severe impairment of liver and kidney function, heart failure, elderly age.

The drug should be applied only to intact skin areas.Avoid contact with eyes or mucous membranes.

If you have any of the listed diseases / conditions, always consult a doctor before taking the drug.

Pregnancy and lactation:The use of the drug in I and II trimester is possible only if the potential benefit to the mother exceeds the risk to the fetus. The use of the drug in the third trimester and lactation is contraindicated.

Dosing and Administration:Outwardly. Adults and children over 12 years. Ointment is applied in an amount of 2 - 4 g (depending on the affected focus) to the affected area 3-4 times a day. Children from 6 to 12 years 1-2 grams 2-3 times a day. The maximum daily dose is 8 g. The course of treatment is 7 - 14 days. Occlusive bandage is not imposed.

Side effects:

From the skin: eczema, photosensitivity, contact dermatitis (itching, hyperemia, swelling of the treated skin, papular-vesicular rashes, peeling).

Allergic reactions (itching and burning of the skin, erythematous skin rash, urticaria, angioedema, systemic anaphylptic reactions (including shock).

When the drug is used in the recommended dose, indications are that side effects are rare.With long-term use and / or application on extensive surfaces, systemic side effects are possible due to resorptive action. If any adverse side reaction occurs, consult a doctor as soon as possible.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Symptoms: Due to low systemic absorption with ointment application, an overdose is unlikely. With accidental ingestion, it is possible to develop systemic adverse reactions.

Treatment for accidental ingestion: gastric lavage, induction of vomiting, Activated carbon, forced diuresis, symptomatic therapy. Dialysis is ineffective due to the high degree of binding to plasma proteins of diclofenac (about 99%).

Interaction:

Interaction with other drugs

May enhance the effect of drugs that cause photosensitivity. Clinically significant interaction with other drugs is unlikely, due to minor systemic absorption.

Special instructions:

Apply only to undamaged skin.After applying, do not apply an occlusive bandage.

With prolonged use and / or application on extensive surfaces, it is possible to develop systemic side effects due to resorptive action. Avoid contact with eyes, mucous membranes or open wounds.

Apply only externally.

Form release / dosage:

Ointment for external use 1%.

Packaging:

30 grams per aluminum tube. Each tube together with instructions for use in a pack of cardboard.

Storage conditions:At a temperature not higher than 15 ° С. Keep out of the reach of children.

Shelf life:2 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-000851

Date of registration:03.08.2010

The owner of the registration certificate:BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus

Manufacturer: & nbsp

BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus

Information update date: & nbsp16.02.2016

Illustrated instructions

Instructions

Diclofenac (Diclofenac)