According to the World Health Organization (WHO)
unwanted reactions are classified according to their frequency of development as follows: very often (>1/10), often (>1/100, <1/10), infrequently (>1/1000, <1/100), rarely (> 1/10000, <1/1000) and very rarely (<1/10000); frequency is unknown - according to available data, it was not possible to establish the frequency of occurrence.
From the gastrointestinal tract:
often: nausea, vomiting, diarrhea, indigestion, abdominal pain, flatulence, anorexia, decreased appetite;
rarely: gastritis, vomiting with an admixture of blood, gastrointestinal
bleeding, melena, gastric or intestinal ulcers, possibly with complications (bleeding, perforation), frequent stools with a trace of blood, proctitis;
rarely: esophagitis, esophageal motility disorder, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease, constipation, stomatitis, glossitis, pancreatitis, exacerbation of hemorrhoids, intestinal adhesions.
From the nervous system:
often: headache, dizziness;
rarely: drowsiness;
rarely: memory impairment, convulsions, anxiety, tremor, aseptic meningitis (usually in patients with systemic lupus erythematosus and other systemic diseases connective tissue), cerebrovascular disorders, disorientation, depression, insomnia, nightmares, irritability, weakness, impaired sensitivity (including paresthesia).
From the sense organs:
often: vertigo;
rarely: noise in the ears, hearing impairment, blurred vision, diplopia, a violation of taste sensations.
From the urinary system:
rarely: acute renal failure, hematuria, proteinuria, nephrotic syndrome, interstitial nephritis, papillary necrosis.
On the part of the organs of hematopoiesis and and lymphatic system:
rarely: anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia
(thrombocytopenic purpura), eosinophilia, agranulocytosis.
From the immune system:
rarely: anaphylactic reactions (including lowering blood pressure (BP) and anaphylactic shock);
rarely: angioedema (including Quincke's edema).
From the respiratory system:
rarely: cough, bronchospasm, swelling larynx;
rarely: pneumonitis.
From the side of cardiovascular system:
infrequently: myocardial infarction, chronic heart insufficiency heart palpitations and pain in the chest;
rarely: increased blood pressure, vasculitis, extrasystole.
From the skin:
often: skin itching, skin rash;
rarely: hives;
rarely: bullous dermatitis, toxic dermatitis, eczema, polymorphic erythema, toxic epidermal necrolysis (syndrome Lyell, Stevens- Johnson), photosensitization.
From the liver and bile excretory ways:
often: increased activity "hepatic" transaminases;
rarely: hepatitis, jaundice, violation liver function;
rarely: hepatitis (possibly fulminant course), necrosis liver, cirrhosis, hepatorenal syndrome, hepatic insufficiency.
Other:
rarely: edema.