Gastrointestinal tract (GIT):
more often 1% - abdominal pain, sensation of bloating, diarrhea, indigestion, nausea, constipation, flatulence, increased activity of "liver" enzymes, peptic ulcer with possible complications (bleeding, perforation), gastrointestinal bleeding;
vomiting, jaundice, melena, the appearance of blood in the stool, the defeat of the esophagus, aphthous stomatitis, dry mouth, hepatitis (possibly fulminant), liver necrosis, cirrhosis, hepatorenal syndrome, anorexia, pancreatitis, cholecystopancreatitis, colitis, gastritis, proctitis, impaired liver function, glossitis, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease.
Nervous system:
more often 1% - headache, dizziness;
less than 1% - sleep disturbance, drowsiness, depression, irritability, aseptic meningitis (more often in patients with systemic lupus erythematosus and other systemic connective tissue diseases), convulsions, weakness, disorientation, nightmares, feelings of fear, sensitivity disorder, incl. , paresthesia, memory disorders, tremor, anxiety, cerebrovascular disorders, mental disorders.
Sense organs: more often 1% - noise in the ears;
less than 1% - blurred vision, diplopia, a taste disorder. Reversible or irreversible hearing loss, scotoma.
Skin:
more often 1% - skin itch, skin rash;
less than 1% - alopecia, urticaria, eczema, toxic dermatitis, multiform exudative erythema, incl. Stevens-Johnson, toxic epidermal necrolysis (Lyell's syndrome), increased photosensitivity, small-point hemorrhage.
Genitourinary system: more often 1% - fluid retention;
less than 1% - nephrotic syndrome, proteinuria, oliguria, hematuria, interstitial nephritis, papillary necrosis, acute renal failure, azotemia.
Hematopoiesis:
less often I% - anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura.
Respiratory system:
less than 1% - cough, bronchospasm, laryngeal edema, pneumonia.
The cardiovascular system:
less than 1% - increased blood pressure; congestive heart failure, extrasystole, chest pain, palpitations, myocardial infarction.
Allergic reactions:
less often 1% - anaphylactoid reactions, anaphylactic shock (usually develops rapidly), swelling of the lips and tongue, allergic vasculitis.
Local reactions:
burning, infiltration, aseptic necrosis, necrosis of adipose tissue.
Other:
less than 1% - worsening of the course of infectious processes (development of necrotizing fasciitis, pneumonia).