The incidence of side effects is classified according to the recommendations of the World Health Organization: it is characterized as very often - at least 10%; often - not less than 1%,but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than <0.1%; very rarely, including individual messages - less
0,01%.
Disorders from the digestive system: often - abdominal pain, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia. Rarely - gastritis, gastrointestinal bleeding, vomiting of blood, melena, diarrhea with a trace of blood, proctitis, ulcers of the stomach and intestines (with or without bleeding or perforation). Very rarely - stomatitis, glossitis, esophagitis, damage to the esophagus, the appearance of diaphragm-like strictures in the intestine, colitis (nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease), constipation, pancreatitis, exacerbation of hemorrhoids.
Disorders from the liver and bile ducts: often - increased activity of "hepatic" transaminases in the serum. Rarely - hepatitis, jaundice, liver function disorders. Very rarely - liver necrosis, hepatic insufficiency, hepatorenal syndrome.
Impaired nervous system: often - headache, dizziness. Rarely, drowsiness. Very rarely - impaired sensitivity, including paresthesia, memory disorders, tremors, convulsions, a sense of anxiety, acute disorders of the brain blood circulation, aseptic meningitis, taste disorders, sensations
Disorders of the psyche: very rarely - disorientation, depression, insomnia, nightmares
dreams, irritability, mental disorders.
Disorders from the side of the organ of vision: very rarely - visual impairment (blurred vision, diplopia).
Hearing disorders and labyrinthine disturbances: often - vertigo; very rarely - hearing impairment, tinnitus.
Disturbances from the skin and subcutaneous tissues: often - skin rash; rarely - hives; very rarely - bullous eruptions, eczema, erythema, erythema multiforme, Stevens-Johnson syndrome, Lyell syndrome (toxic epidermal necrolysis), exfoliative dermatitis, itching, hair loss, photosensitivity reactions; purpura, incl. allergic.
Disorders from the kidneys and urinary tract: very rarely - acute renal failure, hematuria, proteinuria, interstitial nephritis; nephrotic syndrome; papillary necrosis.
Violations from the blood and lymphatic system: very rarely thrombocytopenia, leukopenia, hemolytic anemia, aplastic anemia, agranulocytosis, eosinophilia. Immune system disorders: rarely - hypersensitivity, anaphylactic / anaphylactoid reactions, including lowering blood pressure and shock; very rarely - angioedema.
Disorders from the cardiovascular system: very rarely - a feeling of palpitation, chest pain, heart failure, myocardial infarction, increased blood pressure (BP), vasculitis.
Disturbances from the respiratory system, chest and mediastinal organs: rarely - development of an attack of bronchial asthma (including dyspnea), cough, laryngeal edema; very rarely - pneumonitis.
General disorders and reactions at the site of administration: often - pain, compaction at the injection site; rarely - swelling, necrosis at the injection site, abscess at the injection site.