Diclofenac - instructions for use, dose, side effects, contraindications

The active component of the drug - diclofenac - Non-steroidal anti-inflammatory drug (NSAID), a derivative of phenylacetic acid, has an anti-inflammatory and analgesic effect. Indiscriminately inhibiting cyclooxygenase 1 and 2, disrupts the metabolism of arachidonic acid, reduces the number of prostaglandins, incl. in the hearth of inflammation.

Ointment Diclofenac It is used to eliminate the pain syndrome and reduce the swelling associated with the inflammatory process. When topical application causes weakening and disappearance of joint pain at rest and during movement.Reduces the morning stiffness and swelling of the joints, contributes to an increase in the volume of movements.

At application system absorption is no more than 6%. The connection with proteins is 99.7%. It is excreted by the kidneys. When applied to the area of the affected joint, the concentration in the synovial fluid is higher than in the plasma.

Indications:

- Inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, psoriatic, juvenile chronic arthritis, ankylosing spondylitis, rheumatic soft tissue disorders, gouty arthritis).

- Traumatologically caused inflammation of the tendons, ligaments, muscles and joints (as a result of stretching, with strain and bruises).

- Pain syndrome (lumbago, sciatica, myalgia neuralgia, tendovaginitis, bursitis, rheumatic soft tissue lesions, degenerative diseases of the musculoskeletal system: deforming osteoarthritis, osteochondrosis).

Contraindications:Hypersensitivity to diclofenac or other components of the drug or other NSAIDs, pregnancy (III trimester), younger children (up to 6 years), violation of the integrity of the skin.

Carefully:hepatic porphyria (exacerbation), erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation), severe violations of the liver and kidney function, CHF; bronchial asthma, urticaria or acute rhinitis, triggered by the use of ASA or other NSAIDs; disorders of blood clotting (including hemophilia, prolonged bleeding time, a tendency to bleeding), elderly age, pregnancy I and II trimester, lactation.

Pregnancy and lactation:The drug should not be used in the III trimester of pregnancy. Experience in lactation is not available. Use in I and II trimesters is possible only after consultation with a doctor.

Dosing and Administration:Outwardly. Ointment - 2-4 g is applied in a thin layer, lightly rubbing into the skin, over the inflammation focus 2-3 times a day. The maximum daily dose is 8 g. The course of treatment is 7-14 days. After application, wash hands. The duration of treatment depends on the indications and the therapeutic effect.

Side effects:

Local reactions: eczema, photosensitivity, contact dermatitis (pruritus, hyperemia, edema of the treated area of the skin, papular-vesicular rashes, peeling).

Systemic reactions: allergic reactions (itching and burning of the skin, erythematous skin rash, hives, angioedema, systemic anaphylactic reactions (including shock).

Overdose:Due to low systemic absorption with ointment application, an overdose is unlikely. With accidental ingestion, it is possible to develop systemic adverse reactions that are characteristic of NSAIDs. Treatment: gastric lavage, induction of vomiting, Activated carbon, forced diuresis, symptomatic therapy.

Interaction:The drug may enhance the effect of drugs that cause photosensitivity. Clinically significant interaction with other drugs has not been described.

Special instructions:

Apply only to undamaged skin. After applying, do not apply an occlusive bandage. Avoid contact with eyes, mucous membranes or open wounds.

When using the drug together with other dosage forms of diclofenac, the maximum daily dose should be taken into account.

With prolonged use and / or application on extensive surfaces, it is possible to develop systemic side effects due to resorptive action. Apply only externally.

Effect on the ability to drive transp. cf. and fur:Diclofenac does not affect the ability to drive vehicles and perform work that requires an increased speed of psychomotor reactions.

Form release / dosage:Ointment for external use 1%.

Packaging:30 grams per tube aluminum. By 5, 10, 15, 20, 25, 30 g in cans of dark glass such as BTS made of glass fiber with pull-on lids. The label is self-adhesive on the can.

Each tube or jar, together with the instruction for use, is placed in a cardboard package (pack) of cardboard for

consumer packagings.

Storage conditions:In dry, dark place at a temperature of 15 to 25 ° C. Keep out of the reach of children.

Shelf life:

2 years. Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001330

Date of registration:07.12.2011

Date of cancellation:2016-12-07

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp09.02.2016

Illustrated instructions

Instructions

Diclofenac (Diclofenac)