Diclofenac - instructions for use, dose, side effects, contraindications

Excipients: Carbomer (Arepol) 2.0 g, benzyl benzoate 6.0 g, polysorbate 80 (Tween 80) 1.0 g, methyl parahydroxybenzoate (nipagin) 0.08 g, propyl parahydroxybenzoate (nipazole) 0.02 g, purified water - up to 100.0 g.

Description:Homogeneous ointment from white to white with a greyish-cream color shade.

Pharmacotherapeutic group:Non-steroidal anti-inflammatory drug (NSAID).

ATX: & nbsp

S.01.B.C.03 Diclofenac

M.01.A.B.05 Diclofenac

Pharmacodynamics:The active ingredient is a diclofenacosteroid anti-inflammatory drug with pronounced analgesic and anti-inflammatory properties. Indiscriminately inhibiting cyclooxygenase type 1 and 2, disrupts the metabolism of arachidonic acid and the synthesis of prostaglandins, which are the main link in the development of inflammation. Diclofenac It is used for elimination, pain syndrome and puffiness reduction associated with the inflammatory process.

Pharmacokinetics:At application system absorption is no more than 6%. The connection with proteins is 99.7%. It is excreted by the kidneys. When applied to the area of the affected joint, the concentration in the synovial fluid is higher than in the plasma.

Indications:

Diseases of the musculoskeletal system: rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis of peripheral joints and spine; rheumatic soft tissue damage.

Muscular pain of rheumatic and non-rheumatic origin.

Traumatologically caused inflammation of the tendons, ligaments, muscles and joints (as a result of stretching, with the load and bruises).

Contraindications:Hypersensitivity to diclofenac or other components of the drug, acetylsalicylic acid or other NSAIDs, history of bronchial obstruction, rhinitis, urticaria after ingestion of acetylsalicylic acid or other NSAIDs, pregnancy (III trimester), lactation period, children's age (up to 6 years), violation the integrity of the skin at the site of the intended application.

Carefully:Hepatic porphyria (exacerbation), erosive-ulcerative lesions.gastrointestinal tract, severe impairment of liver and kidney function, chronic heart failure, bronchial asthma, elderly age, children age from 6 to 12 years, disorders of blood clotting (including hemophilia, lengthening bleeding time, propensity to bleed, pregnancy (I and II trimesters).

Dosing and Administration:Outwardly. Adults and children over 6 years of the drug is applied to the skin 3-4 times a day lightly rubbed. The required amount of the drug depends on the size of the painful area. A single dose of the drug from 2 to 4 grams (from-4 to 8 cm with a fully open neck of the tube). Children from 6 to 12 years of age, the drug is applied no more than 2 times a day, a single dose of the drug to 2 g. The duration of treatment without consulting a doctor should not exceed 10 days.

Side effects:

Local reactions: eczema, photosensitivity, contact dermatitis (itching, redness, swelling of the treated area of the skin, papules, vesicles, peeling).

Systemic reactions: generalized skin rash, allergic reactions (urticaria, angioedema, bronchospastic reactions), systemic anaphylactic reactions (including shock).

Overdose:

Extremely low systemic absorption of active components of the drug with external application makes an overdose almost impossible.

With accidental ingestion, it is possible to develop systemic adverse reactions.

Treatment: gastric lavage, induction of vomiting, reception of activated carbon, forced diuresis, symptomatic therapy. Dialysis is not effective due to the high degree of binding to diclofenac proteins (about 99%).

Interaction:Diclofenac can enhance the effect of drugs that cause photosensitivity. Clinically significant interaction with other drugs has not been described.

Special instructions:Diclofenac Should be applied only to intact skin, avoiding contact with open wounds. After applying, do not apply an occlusive dressing. Do not allow the drug to enter the eyes and mucous membranes. With long-term use and / or application on extensive surfaces, it is possible to develop systemic side effects, due to resorptive action.

Form release / dosage:Ointment for external use 2%.

Packaging:Ointment for external use 2% to 30 g in aluminum tubes.Each tube, together with the instruction, for medical use of the drug is placed in a cardboard box.

Storage conditions:At a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:2 years. Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-001354/10

Date of registration:25.02.2010

The owner of the registration certificate:MUROMSKY INSTRUMENT-MAKING PLANT, OJSC MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia

Manufacturer: & nbsp

MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia

Information update date: & nbsp19.02.2016

Illustrated instructions

Instructions

Diclofenac (Diclofenac)