Often - 1-10%; sometimes 0.1-1%; rarely 0.01-0.1%; very rarely - less, 0.001%, including individual cases.
From the digestive side. system: often - epigastric pain, nausea, vomiting, diarrhea; dyspepsia; flatulence, anorexia, increased activity of aminotransferases; rarely - gastritis, proctitis, bleeding from the digestive tract (vomiting with blood, melena,diarrhea mixed with blood), gastrointestinal ulcers (with or without bleeding or perforation g), hepatitis, jaundice, liver dysfunction; very rarely - stomatitis, glossitis, -Damage esophagus, bowel strictures diafragmopodobnye (nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease), constipation, pancreatitis, fulminant hepatitis, exacerbation of hemorrhoids.
From the nervous system: often headache, dizziness, rarely - drowsiness; very rarely - a violation of sensitivity, incl. paresthesia, memory disorders, tremors, convulsions; anxiety, cerebrovascular disorders, aseptic meningitis, disorientation, depression; insomnia, night "nightmares", irritability, personality disorders.
From the sense organs: often - vertigo; very rarely - blurred vision (blurred vision, diplopia), impaired hearing, tinnitus, taste disturbance.
From the urinary system: very rarely - acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.
On the part of the blood-forming organs: very rarely - thrombocytopenia, leukopenia, hemolytic and aplastic anemia, agranulocytosis.
Allergic reactions: anaphylactic / anaphylactoid reactions, including a marked decrease in blood pressure and shock; very rarely - angioedema (including face).
From the side, the cardiovascular system: very rarely - palpitations, chest pain, increased blood pressure; vasculitis, heart failure, myocardial infarction.
Co the respiratory system: rarely - bronchial asthma (including, dyspnea); very rarely pneumonitis.
From the skin: often - skin rash; rarely - hives; very rarely - bullous eruptions, eczema, incl. multiform and Stevens-Johnson syndrome, Lyell's syndrome, exfoliative dermatitis, itching, hair loss, photosensitivity, purpura, incl. allergic.
Local reactions with rectal administration: irritation of the mucous membrane of the rectum, mucous discharge with an admixture of blood, pain during defecation, rectal bleeding.